Effect of Indian Almond Leaf (Terminalia catappa L.) Extract on The Duodenal Digestive Enzyme Activity of Diabetic Mice (Mus musculus)
In the current global era, diabetic has become the most common illness ranging from young to old age groups. The usage of synthetic drugs to treat diabetic has very dangerous effect on the body because it can cause side effect in the long term so that needed drugs from natural ingredients to prevent the effect side. This research aimed to determine the effect of Indian Almond extract (125 mg/kg BW, 250 mg/kg BW, 500 mg/kg BW, and 750 mg/kg BW) on the duodenal digestive enzyme of diabetic mice. This research used 30 male mice which were 2 months old with total group 10 units that consisted of 1 negative control group (K-), 1 positive control group (K+), and 8 treatment groups. Each group consisted 3 repetitions. The research result showed that, there were no significant differences among amylase enzyme activity negative control (K-), positive control (K+), and all treatment groups. Meanwhile, on the lypase enzyme activity were also found no significant differences among negative contol (K-), positive control (K+), and the most of the treatments. However, on the mice group with doses 750 mg/kg BW green leaf showed the highest value of lypase enzyme activity and on the mice group with dose 250 mg/kg BW dried leaf showed the lowest value of lypase enzyme activity. Further, on the protease enzyme activity were found no significant differences among negative control (K-), positive control (K+), and the most of the treatments. However, on mice group with dose 500 mg/kg BW dried leaf showed that lypase activity was inhibited so that the value of its activity has decreased.